R. Venkataramani has represented several State Governments, Universities, Central and State Public Sector Undertakings in Supreme Court and High Courts. He has been a Special Senior Counsel for various departments of Government of India in Supreme Court and High Courts between 2004–2010 and also been acting as Counsel for the Supreme Court in matters pertaining to the service conditions of employees of the Court.

His professional engagements and areas of interest has been actively involved in academic activities, since 1988 commencing from his association with the National Law School of India University, Bangalore and is engaged with several law schools in their academic activities. Concerned with reforms in legal education, law research and socially relevant institutional developments, Mr. Venkataramani is a member academic council of Visva Bharati, (Shantiniketan) member board of studies of school of law Bennett University, Adjunct faculty in several Law Schools including Jindal Global University.

He is interested in promoting comparative law studies and in exploring new areas of legal theory and jurisprudence, such as law and science, technology and public policy, and international law and its impact on domestic law. He is also keen to contribute towards inclusive growth, diversity element in institutions of law and justice and to use law as an instrument of peace and goodwill.

He was enrolled in July, 1977 in the Bar Council of Tamil Nadu, joined the chambers of Mr. P.P. Rao, Senior Advocate, Supreme Court in 1979 and set up independent practice in Supreme Court in1982, designated as Senior Advocate by the Supreme Court of India in the year 1997 and appointed as a Member of the Law Commission of India in 2010 and again for a further term in 2013.

His other professional engagements was a Member of the Sub-Committee on Directive Principles of State Policy, constituted by the Commission reviewing the working of the Constitution under the Chairmanship of Justice M. N. Venkatachaliah.

Co-opted member of the Expert Group constituted by the Ministry of Minority Affairs under the chairmanship of Late Prof. N. R. Madhava Menon to examine and determine the structure and functions of an Equal Opportunity Commission he has also served as Member of the Ethics Committee of the Indian Council for Medical Research, Member of the Supreme Court Legal Aid Committee for many years, Co. chair of the Asian Jural Conclave being organized by Menon Institute of Legal Advocacy and Training and Lloyds Law School, a honorary capacity as the Administrator Cum Receiver of Amrapali Real Estate Projects under orders of the Supreme Court. He was also Member cum office bearer of several Lawyers’ Associations, National and International, Life Member of Indian Society of International Law, Resource person of the Society for its Annual Summer Courses and actively participating in the Projects of the Society.